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NIK SMI1

Cat. No. M9949
NIK SMI1 Structure
Synonym:

NIK-SMI1

Size Price Availability Quantity
5mg USD 490  USD490 In stock
10mg USD 740  USD740 In stock
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Quality Control & Documentation
Biological Activity

NIK SMI1 is a highly selective and potent NF-κB-inducing kinase (NIK) inhibitor. NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo.

Chemical Information
Molecular Weight 365.38
Formula C20H19N3O4
CAS Number 1660114-31-7
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiang Wang, et al. NIK inhibitor impairs chronic periodontitis via suppressing non-canonical NF-κB and osteoclastogenesis

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Keywords: NIK SMI1, NIK-SMI1 supplier, NF-κB, inhibitors, activators


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