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Neticonazole Hydrochloride

Cat. No. M8980
Neticonazole Hydrochloride Structure
Synonym:

Neticonazole HCl

Size Price Availability Quantity
50mg USD 150 In stock
100mg USD 220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 338.9
Formula C17H22N2OS.HCl
CAS Number 130773-02-3
Purity >98%
Solubility DMSO: ≥ 50 mg/mL
Storage at -20°C
References

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.
Datta A, et al. Sci Rep. 2018 May 25;8(1):8161. PMID: 29802284.

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  Catalog
Abmole Inhibitor Catalog 2017




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