Free shipping on all orders over $ 500

Netarsudil (AR-13324) 2HCl

Cat. No. M11034
Netarsudil (AR-13324) 2HCl Structure
Synonym:

AR-13324

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies.

Chemical Information
Molecular Weight 526.45416
Formula C28H29Cl2N3O3
CAS Number 1253952-02-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related ROCK Products
Akt/ROCK-IN-1

Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively.

Scaff10-8

Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation.

ROCK-IN-6

ROCK-IN-6 is a potent and selectiveROCK2 inhibitor with an IC50 of 2.19 nM.

ROCK-IN-4

ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability.

ROCK-IN-32

ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2.

  Catalog
Abmole Inhibitor Catalog




Keywords: Netarsudil (AR-13324) 2HCl, AR-13324 supplier, ROCK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.