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Nepafenac

Cat. No. M2233
Nepafenac Structure
Synonym:

Nevanac

Size Price Availability Quantity
10mg USD 40  USD40 In stock
25mg USD 50  USD50 In stock
50mg USD 90  USD90 In stock
100mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

Nepafenac is an analgesic selective inhibitor of COX-2. Nepafenac is also a non-steroidal anti-inflammatory with analgesic activity. Nepafenac is used to treat pain and inflammation associated with cataract surgery.

Chemical Information
Molecular Weight 254.28
Formula C15H14N2O2
CAS Number 78281-72-8
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Athanasios Bezatis, et al. Nepafenac in cataract surgery

[2] Selim Cevher, et al. How does nepafenac affect the choroidal thickness after uneventful cataract surgery?

[3] No authors listed. Nepafenac

[4] No authors listed. Aust Prescr. Nepafenac

[5] Benjamin M Jones, et al. Nepafenac: an ophthalmic nonsteroidal antiinflammatory drug for pain after cataract surgery

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  Catalog
Abmole Inhibitor Catalog




Keywords: Nepafenac, Nevanac supplier, COX, inhibitors, activators


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