Neomycin sulfate belongs to a class of antibiotics known as the aminoglycosides. Neomycin sulphate belongs to a class of antibiotics known as the aminoglycosides. Neomycin sulphate is bactericidal in action (kills bacteria). Neomycin sulphate (Neomycin sulphate) does this by causing the bacteria to produce defective proteins which are essential for their growth. Neomycin sulphate is an antibiotic, active against many strains of Gram-positive and Gram-negative bacteria including Staph. aureus, E. coli, Klebsiella spp., H. influenzae, S. typhi, Shigella and Mycobacterium tuberculosis. It is ineffective against fungi and viruses.
Microbiol Res. 2022 Aug;261:127047.
Interaction between gut microbiota dysbiosis and lung infection as gut-lung axis caused by Streptococcus suis in mouse model
Neomycin sulfate purchased from AbMole
| Molecular Weight | 712.72 |
| Formula | C23H46N6O13.H2SO4 |
| CAS Number | 1405-10-3 |
| Solubility (25°C) | Water 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Tunc Catal, et al. Monitoring of neomycin sulfate antibiotic in microbial fuel cells
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