Synonym: Arranon, 506U78
Nelarabine (Arranon, 506U78) is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Nelarabine is well tolerated and has significant antitumor activity in T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL). Nelarabine (506U78) has activity in T-cell malignancies, as evaluated in 2 Phase I and 5 Phase II studies. The mRNA levels of the transporters ENT1 and ENT2 were higher in Nelarabine-sensitive than -resistant samples.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 60 mg/mL|
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia.
Homminga I, et al. Blood. 2011 Aug 25;118(8):2184-90. PMID: 21730354.
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ. Hematol Oncol Clin North Am. 2009 Oct;23(5):1121-35, vii-viii. PMID: 19825456.
|Related DNA/RNA Synthesis Products|
Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers.
Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.