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Nelarabine

Cat. No. M1916

Nelarabine Structure

Synonym: Arranon, 506U78

Size Price Availability Quantity
10mg USD 160 In stock
50mg USD 500 In stock
100mg USD 840 In stock
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Quality Control
Biological Activity

Nelarabine (Arranon, 506U78) is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Nelarabine is well tolerated and has significant antitumor activity in T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL). Nelarabine (506U78) has activity in T-cell malignancies, as evaluated in 2 Phase I and 5 Phase II studies. The mRNA levels of the transporters ENT1 and ENT2 were higher in Nelarabine-sensitive than -resistant samples.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 297.27
Formula C11H15N5O5
CAS Number 121032-29-9
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia.
Homminga I, et al. Blood. 2011 Aug 25;118(8):2184-90. PMID: 21730354.

Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ. Hematol Oncol Clin North Am. 2009 Oct;23(5):1121-35, vii-viii. PMID: 19825456.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nelarabine, Arranon, 506U78 supplier, DNA/RNA Synthesis, inhibitors

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