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Naratriptan

Cat. No. M3472
Naratriptan Structure
Synonym:

GR-85548A hydrochloride

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50mg USD 170  USD170 Out of stock
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Quality Control & Documentation
Biological Activity

Naratriptan is a compound in the triptans family that has been studied for migraine.

Chemical Information
Molecular Weight 371.93
Formula C17H25N3O2S.HCl
CAS Number 143388-64-1
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peer Tfelt-Hansen. Naratriptan is as effective as sumatriptan for the treatment of migraine attacks when used properly. A mini-review

[2] Hassan Aboul Nour, et al. Naratriptan-Associated Spinal Artery Infarction

[3] No authors listed. Naratriptan

[4] H Massiou. Naratriptan

[5] R Salonen. Naratriptan

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