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Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 377.86 |
| Formula | C20H24ClNO4 |
| CAS Number | 16676-29-2 |
| Purity | >98% |
| Solubility | 14 mg/mL in DMSO |
| Storage | at -20°C |
| Related Opioid Receptor Products |
|---|
| Met-Enkephalin
Met-Enkephalin (H-Tyr-Gly-Gly-Phe-Met-OH) inhibits tumor growth via binding to the opioid receptor. |
| Trimebutine maleate
Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects. |
| Trimebutine
Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain. |
| Docusate Sodium
Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally. |
| Alvimopan dihydrate
Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. |
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