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NADH

Cat. No. M4989
NADH Structure
Synonym:

beta-NADH disodium salt

Size Price Availability Quantity
100mg USD 40  USD40 In stock
500mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

NADH disodium salt is a coenzyme of a large number of oxidoreductases. NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle. β-Nicotinamide adenine dinucleotide (β-NADH) reduced form is an essential cofactor in all the living organisms. β-NADH functions as a hydride donor in biochemical redox reactions.

Product Citations
Chemical Information
Molecular Weight 709.4
Formula C21H27N7Na2O14P2
CAS Number 606-68-8
Solubility (25°C) Water: ≥ 50 mg/mL
Storage -20°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Weihai Ying. Front Biosci. NAD+ and NADH in cellular functions and cell death

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