NAD+, nicotinamide adenine dinucleotide, is a coenzyme that transfers hydrogen ions and is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5'-phosphate via pyrophosphate bonding.NAD+ is the oxidized form of NADH.NAD+ is a coenzyme that is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5 '-phosphate coupled by pyrophosphate bonding.
Nat Commun. 2021 Mar 8;12(1):1513.
Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis
NAD+ purchased from AbMole
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Source | Nat Commun (2021 Mar). Figure 1. NAD+ (Abmole Bioscience) |
| Method | Protein expression and enzyme activities | |
| Cell Lines | Plasmids p90, p91, p92, and p98 | |
| Concentrations | 2.0 mM | |
| Incubation Time | 1 min | |
| Results | 3HP production via metabolic engineering started from 1,3-propanediol could avoid the paradox between glycerol dehydratase and aldehyde dehydrogenase activities, which generate from the imbalance of vita min B12 synthesis and NAD+ regeneration. |
| Molecular Weight | 663.43 |
| Formula | C21H27N7O14P2 |
| CAS Number | 53-84-9 |
| Solubility (25°C) | Water 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Luis Rajman, et al. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
[5] G Sultani, et al. NAD + : A key metabolic regulator with great therapeutic potential
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