N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs. N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs.
Adv Sci (Weinh). 2023 Jul 3;e2300892.
The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice
N6-Methyladenosine purchased from AbMole
| Molecular Weight | 281.27 |
| Formula | C11H15N5O4 |
| CAS Number | 1867-73-8 |
| Solubility (25°C) | DMSO 36 mg/mL Water 14 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Wang X, et al. Nature. N6-methyladenosine-dependent regulation of messenger RNA stability.
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