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N-(Ketocaproyl)-D,L-homoserine lactone

Cat. No. M9847
N-(Ketocaproyl)-D,L-homoserine lactone Structure
Synonym:

N-(Beta-Ketocaproyl)-DL-Homoserine Lactone

Size Price Availability
25mg USD 780  USD780 Custom Synthesis
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Quality Control & Documentation
Biological Activity

N-(Ketocaproyl)-D,L-homoserine lactone is a natural, active ligand of LuxR. N-(Ketocaproyl)-D,L-homoserine lactone is also a quorum sensing (QS) autoinducer.

Chemical Information
Molecular Weight 213.23
Formula C10H15NO4
CAS Number 76924-95-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Si-Zhe Li, et al. Bioorg Chem. Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity

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Keywords: N-(Ketocaproyl)-D,L-homoserine lactone, N-(Beta-Ketocaproyl)-DL-Homoserine Lactone supplier, Anti-infection, inhibitors, activators


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