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N-Glycolylneuraminic acid

Cat. No. M19972
N-Glycolylneuraminic acid Structure
Synonym:

NeuGc; GcNeu

Size Price Availability Quantity
5mg USD 115  USD115 In stock
10mg USD 185  USD185 In stock
25mg USD 325  USD325 In stock
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Quality Control & Documentation
Biological Activity

N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs).

Chemical Information
Molecular Weight 325.27
Formula C11H19NO10
CAS Number 1113-83-3
Solubility (25°C) Water ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cindy M Spruit, et al. J Virol. N-Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses

[2] Renato Mastrangeli, et al. Trends Pharmacol Sci. Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins

[3] Sharon Yehuda, et al. Front Immunol. Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid

[4] Andrea Perota, et al. Front Immunol. N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)

[5] Anoopjit Singh Kooner, et al. Front Immunol. Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides

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Keywords: N-Glycolylneuraminic acid, NeuGc; GcNeu supplier, Anti-infection, inhibitors, activators


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