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Myxothiazol

Cat. No. M13386
Myxothiazol  Structure
Size Price Availability Quantity
1mg USD 400  USD400 In stock
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Biological Activity

Myxothiazol, an antifungal antibiotic, is an inhibitor of mitochondrial electron transport chain complex III (Complex III or Bc1 complex).

Chemical Information
Molecular Weight 487.68
Formula C25H33N3O3S2
CAS Number 76706-55-3
Form Solid
Solubility (25°C) N/A
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ann-Katrin Hopp, et al. Mol Cell. Mitochondrial NAD + Controls Nuclear ARTD1-Induced ADP-Ribosylation

[2] Veronika Zelinov, et al. Protoplasma. Impact of antimycin A and myxothiazol on cadmium-induced superoxide, hydrogen peroxide, and nitric oxide generation in barley root tip

[3] A A Starkov, et al. Biochem Biophys Res Commun. Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain

[4] G Thierbach, et al. Biochim Biophys Acta. Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of th respiratory chain

[5] W D Parker Jr, et al. Biochim Biophys Acta. Myxothiazol resistance in human mitochondria

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