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MSX-122

Cat. No. M5165
MSX-122 Structure
Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 100 In stock
50mg USD 350 In stock
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Quality Control
Biological Activity

MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). MSX-122 blocks invasion and angiogenesis in vitro. MSX-122 attenuates colonic damage in mice with experimental colitis. MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 292.34
Formula C16H16N6
CAS Number 897657-95-3
Purity 100.00%
Solubility DMSO 10 mM
Storage at -20°C
References

Development of a unique small molecule modulator of CXCR4.
Liang Z, et al. PLoS One. 2012;7(4):e34038. PMID: 22485156.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MSX-122 supplier, CXCR, inhibitors

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