MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water: ≥ 55 mg/mL|
Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models.
Sun XL, et al. J Neuroinflammation. 2016 Jul 8;13(1):180. PMID: 27391369.
Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.
Desole MS, et al. Pharmacol Biochem Behav. 1996 Jun;54(2):377-83. PMID: 8743598.
Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.
Hsu KS, et al. Neuropharmacology. 1993 Sep;32(9):877-83. PMID: 7901791.
|Related Dopamine Receptor Products|
SCH23390 is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively).
SKF38393 HCl is a selective D1 dopamine receptor agonist with IC50 of 110 nM.
|SCH 23390 hydrochloride
SCH 23390 hydrochloride is a standard selective D 1-like antagonist; also 5-HT 2C and 5-HT 1C agonist and K ir3 channel blocker.
Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.
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