Free shipping on all orders over $ 500

Molidustat (BAY 85-3934)

Cat. No. M5795
Molidustat (BAY 85-3934) Structure
Synonym:

BAY 85-3934

Size Price Availability Quantity
10mM*1mL in DMSO USD 115  USD115 In stock
5mg USD 90  USD90 In stock
10mg USD 160  USD160 In stock
50mg USD 380  USD380 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. 

Chemical Information
Molecular Weight 314.30
Formula C13H14N8O2
CAS Number 1154028-82-6
Solubility (25°C) 3 mg/mL warmed in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Flamme I, et al. PLoS One. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.

Related HIF Products
3-Aminobenzoic acid

3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.

Steppogenin

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.

HIV-IN-7

Axl-IN-16 is a Axl inhibitor.

HIF-2α-IN-9

HIF-2α-IN-9 is an inhibitor ofHIF-2α.

PHD-IN-2

PHD-IN-2 is a PHD antagonist (IC50: < 5 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: Molidustat (BAY 85-3934), BAY 85-3934 supplier, HIF, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.