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Molidustat (BAY 85-3934)

Cat. No. M5795
Molidustat (BAY 85-3934) Structure
Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 150 In stock
50mg USD 600 In stock
100mg USD 900 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 314.30
Formula C13H14N8O2
CAS Number 1154028-82-6
Purity >99%
Solubility 3 mg/mL warmed in DMSO
Storage at -20°C
References

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
Flamme I, et al. PLoS One. 2014 Nov 13;9(11):e111838. PMID: 25392999.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Molidustat (BAY 85-3934) supplier, HIF, inhibitors

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