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MMAF

Cat. No. M5041
MMAF Structure
Synonym:

Monomethylauristatin F

Size Price Availability Quantity
2mg USD 180 In stock
5mg USD 330 In stock
10mg USD 540 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE).

Customer Product Validations & Biological Datas
Source J Control Release (2018). Figure 2. MMAF
Method MTT assay
Cell Lines SK-MEL 2 cells
Concentrations 1 nM
Incubation Time 120 h
Results All together, these observations show that EV20/MMAF is endowed with a potent and target-dependent cell killing activity.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 731.96
Formula C39H65N5O8
CAS Number 745017-94-1
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MMAF, Monomethylauristatin F supplier, Microtubule, inhibitors

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