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ML327

Cat. No. M9309
ML327 Structure
Synonym:

ML-327

Size Price Availability Quantity
10mM*1mL In DMSO USD 530 In stock
2mg USD 465 In stock
5mg USD 660 In stock
10mg USD 995 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ML327 is a blocker of MYC, which mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition. ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand. ML327 blocks the expression of MYC family of oncogenic transcription factors in all tested neuroblastoma cell lines. ML327 reduces SW620inv cell invasion through Matrigel by ~60% and reduces H520 cell invasion by ~30% in these in vitro assays. 

In vivo, ML327 treatment significantly reduces tumor volume by three-fold over the two-week treatment period (p=0.02). Tumor explant weights are approximately three-fold smaller in the ML327-treated mice (p=0.01). Mice treated with ML327 lost 12% more body weight than vehicle treated mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 366.37
Formula C19H18N4O4
CAS Number 1883510-31-3
Purity >98%
Solubility DMSO: ≥ 21 mg/mL (Need warming)
Storage at -20°C
References

Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma.
Rellinger EJ, et al. Oncotarget. 2017 Jul 20;8(53):91040-91051. PMID: 29207623.

ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand.
Rellinger EJ, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):463-468. PMID: 28716733.

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition.
An H, et al. Oncotarget. 2015 Sep 8;6(26):22934-48. PMID: 26082441.

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Keywords: ML327, ML-327 supplier, c-Myc, inhibitors

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