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ML167

Cat. No. M2858
ML167 Structure
Synonym:

CID 44968231

Size Price Availability
10mg USD 130  USD130 Out of stock
50mg USD 450  USD450 Out of stock
100mg USD 800  USD800 Out of stock
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Quality Control & Documentation
Biological Activity

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.

Chemical Information
Molecular Weight 335.36
Formula C19H17N3O3
CAS Number 1285702-20-6
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pooja S Panicker, et al. Epidermal growth factor receptor (EGFR) structure-based bioactive pharmacophore models for identifying next-generation inhibitors against clinically relevant EGFR mutations

[2] Andrew S Rosenthal, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4)

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  Catalog
Abmole Inhibitor Catalog




Keywords: ML167, CID 44968231 supplier, CDK, inhibitors, activators


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