Free shipping on all orders over $ 500

MK-3903

Cat. No. M9764
MK-3903 Structure
Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 220  USD220 In stock
50mg USD 650  USD650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 binds moderately to the prostanoid DP2 (CRTH2) receptor (binding IC50=1.8 μM) but not in the presence of 10% human serum (binding IC50>86 μM).

In vivo, oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses.

Chemical Information
Molecular Weight 454.9
Formula C27H19ClN2O3
CAS Number 1219737-12-8
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ping Lan, et al. J Med Chem. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

Related AMPK Products
SAMS

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

Marein

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway.

Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy.

AMPK activator 12

AMPK activator 12 is a potent AMPK activator and GDF15 inducer.

Kazinol U

Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation.

  Catalog
Abmole Inhibitor Catalog




Keywords: MK-3903 supplier, AMPK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.