MK-3118

Cat. No. M10473

Synonym:

SCY-078; MK3118

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Quality Control

Current batch:
Purity >98%
COA
MSDS

Product Information

Biological Activity

MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins.

In vivo animal models have demonstrated efficacy in murine models of invasive candidiasis, aspergillosis, and pneumocystis. Due to high bioavailability, MK-3118 can be administered both orally and intravenously.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

Molecular Weight	730.03
Formula	C44H67N5O4
CAS Number	1207753-03-4
Purity	>98%

Solubility
Storage	at -20°C

References

[1] Frederic Lamoth, et al. Antimicrob Agents Chemother. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates

[2] Alexander J Lepak, et al. Antimicrob Agents Chemother. Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model

[3] Cristina Jimenez-Ortigosa, et al. Antimicrob Agents Chemother. Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates

[4] Michael A Pfaller, et al. Antimicrob Agents Chemother. In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods

[5] Michael A Pfaller, et al. J Antimicrob Chemother. Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST)

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Signaling Pathways

Product Type

MK-3118

SCY-078; MK3118

Quality Control

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Chemical Information

References

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