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Mitoquinone mesylate

Cat. No. M9068
Mitoquinone mesylate Structure
Synonym:

MitoQ10 mesylate

Size Price Availability
10mg USD 166.5  USD185 Out of stock
25mg USD 351  USD390 Out of stock
50mg USD 621  USD690 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant. The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg.

Product Citations
Customer Product Validations & Biological Datas
Source Redox Biol (2020 Oct), Figure 6, Mitoquinone mesylate (Abmole Bioscience)
Method Cell culture and treatment
Cell Lines BMDMs and PMs
Concentrations 250 and 500 nM
Incubation Time 15 min
Results Furthermore, inhibition of mitochondrial ROS production with MitoQ abrogated LPS-induced TNF-α and IL-6 expression
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 678.81
Formula C38H47O7PS
CAS Number 845959-50-4
Purity >98%
Solubility DMSO: ≥ 18 mg/mL
Storage at -20°C
References

Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis.
Huang W, et al. Mediators Inflamm. 2015;2015:901780. PMID: 25878403.

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys.
Mitchell T, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92. PMID: 21159749.

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  Catalog
Abmole Inhibitor Catalog 2017




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