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Mitoquinone mesylate

Cat. No. M9068
Mitoquinone mesylate Structure
Synonym:

MitoQ10 mesylate

Size Price Availability
10mg USD 185  USD185 Out of stock
25mg USD 390  USD390 Out of stock
50mg USD 690  USD690 Out of stock
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Quality Control & Documentation
Biological Activity

Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant. The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg.

Product Citations
Customer Product Validations & Biological Datas
Source Redox Biol (2020 Oct), Figure 6, Mitoquinone mesylate (Abmole Bioscience)
Method Cell culture and treatment
Cell Lines BMDMs and PMs
Concentrations 250 and 500 nM
Incubation Time 15 min
Results Furthermore, inhibition of mitochondrial ROS production with MitoQ abrogated LPS-induced TNF-α and IL-6 expression
Chemical Information
Molecular Weight 678.81
Formula C38H47O7PS
CAS Number 845959-50-4
Form Oil
Solubility (25°C) DMSO: ≥ 18 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huang W, et al. Mediators Inflamm. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis.

[2] Mitchell T, et al. J Pharmacol Exp Ther. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys.

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