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(-)-Taxifolin

Cat. No. M11479
(-)-Taxifolin Structure
Synonym:

(-)-Dihydroquercetin

Size Price Availability Quantity
5mg USD 720  USD720 In stock
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Quality Control
  • Current batch:
  • Purity N/A
  • COA
  • MSDS
Biological Activity

(-)-Taxifolin is a low activity isomer of Taxifolin. Taxifolin has important anti-tyrosinase activity. Taxifolin effectively inhibited collagenase with IC50 of 193.3 μM. Taxifolin is an important natural compound with anti-fibrosis effects. Taxifolin is a free radical scavenger with antioxidant capacity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 304.25
Formula C15H12O7
CAS Number 111003-33-9
Purity N/A
Solubility N/A
Storage 2-8℃
References

[1] Fernanda Cristina Stenger Moura, et al. Pharmaceutics. Exploring Taxifolin Polymorphs: Insights on Hydrate and Anhydrous Forms

[2] Satoshi Saito, et al. Front Pharmacol. Taxifolin: A Potential Therapeutic Agent for Cerebral Amyloid Angiopathy

[3] Zi-Ying Zhan, et al. Food Funct. Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis

[4] Sandra Gunesch, et al. Redox Biol. 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

[5] Christudas Sunil, et al. Phytochemistry. An insight into the health-promoting effects of taxifolin (dihydroquercetin)

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