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Mibefradil dihydrochloride

Cat. No. M14201
Mibefradil dihydrochloride Structure
Synonym:

Ro 40-5967 dihydrochloride

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively).

Chemical Information
Molecular Weight 568.55
CAS Number 116666-63-8
Solubility (25°C) Water ≥ 90 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dai Ying, et al. Mibefradil reduces hepatic glucose output in HepG2 cells via Ca 2+/calmodulin-dependent protein kinase II-dependent Akt/forkhead box O1signaling

[2] Ling-Gong Zhao, et al. Mibefradil Alleviates High-Glucose-induced Cardiac Hypertrophy by Inhibiting PI3K/Akt/mTOR-mediated Autophagy

[3] H A Welker, et al. Clinical pharmacokinetics of mibefradil

[4] B M Massie. Mibefradil: a selective T-type calcium antagonist

[5] T D Giles. Mibefradil (posicor)

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Keywords: Mibefradil dihydrochloride, Ro 40-5967 dihydrochloride supplier, Calcium Channel, inhibitors, activators


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