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MI-2

Cat. No. M9145
MI-2 Structure
Synonym:

Menin-MLL Inhibitor 2

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MI-2 (Menin-MLL Inhibitor 2) is a potent menin-MLL interaction inhibitor with IC50 of 446±28 nM. In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 375.55
Formula C18H25N5S2
CAS Number 1271738-62-5
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Grembecka J, et al. Nat Chem Biol. 2012 Jan 29;8(3):277-84. PMID: 22286128.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MI-2, Menin-MLL Inhibitor 2 supplier, Histone Methyltransferase, inhibitors

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