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Metoprolol Tartrate

Cat. No. M5785
Metoprolol Tartrate Structure
Synonym:

CGP 2175E

Size Price Availability Quantity
100mg USD 112  USD140 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 684.81
Formula 2C15H25NO3.C4H6O6
CAS Number 56392-17-7
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

[1] Fleet JL, et al. Am J Kidney Dis. Kidney function and population-based outcomes of initiating oral atenolol versus metoprolol tartrate in older adults.

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