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Metipranolol hydrochloride

Cat. No. M13895
Metipranolol hydrochloride Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Metipranolol hydrochloride is a non-selective β adrenergic receptor blocking agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 345.86
Formula
CAS Number 36592-77-5
Purity >99%
Solubility DMSO 90 mg/mL
Water ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Steven D Vold, et al. Cost analysis of glaucoma medications: a 3-year review

[2] G E Mirza, et al. Comparison of the effects of 0.5% timolol maleate, 2% carteolol hydrochloride, and 0.3% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic effects

[3] W C Stewart, et al. Daily cost of beta-adrenergic blocker therapy

[4] V Knezl, et al. Effect of the new beta-adrenolytic compound propyl-3-acetyl-4-[(2-hydroxy-3-isopropylamino) propoxy]carbanylate hydrochloride on isolated heart muscle

[5] M Ober, et al. [Local subjective tolerance of levobunolol and metipranolol in a double-blind comparative study in patients with increased intraocular pressure]

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