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Methscopolamine bromide

Cat. No. M3589
Methscopolamine bromide Structure
Synonym:

(-)-Scopolamine methyl bromide; Hyoscine methyl bromide

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 35  USD35 In stock
50mg USD 55  USD55 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Methscopolamine is a muscarinic acetylcholine receptors blocker. It is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. It also may work directly on the vomiting center. Methscopolamine bromide must be taken before the onset of motion sickness to be effective. It acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Chemical Information
Molecular Weight 398.29
Formula C18H24BrNO4
CAS Number 155-41-9
Solubility (25°C) DMSO 70 mg/mL
Water 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maninder Pal Singh, et al. Development and Optimization of Methscopolamine Bromide Gastroretentive Floating Tablets Using 32 Factorial Design

[2] No authors listed. Methscopolamine Bromide

[3] F E VISSCHER, et al. Pharmacology of pamine bromide

[4] D K Aaron, et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide

[5] J A Daniel, et al. Methscopolamine bromide blocks hypothalamic-stimulated release of growth hormone in ewes

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Keywords: Methscopolamine bromide, (-)-Scopolamine methyl bromide; Hyoscine methyl bromide supplier, AChR/AChE, inhibitors, activators


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