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Methscopolamine bromide

Cat. No. M3589
Methscopolamine bromide Structure
Synonym:

(-)-Scopolamine methyl bromide; Hyoscine methyl bromide

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 80 In stock
200mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Methscopolamine (Pamine)is a muscarinic acetylcholine receptors blocker. It is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. It also may work directly on the vomiting center. Methscopolamine bromide must be taken before the onset of motion sickness to be effective. It acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 398.29
Formula C18H24BrNO4
CAS Number 155-41-9
Purity >98%
Solubility DMSO 70 mg/mL
Water 70 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Methscopolamine bromide, (-)-Scopolamine methyl bromide; Hyoscine methyl bromide supplier, AChR/AChE, inhibitors

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