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Cat. No. M1952
Methionine Structure

D-Methionine; MRX-1024

Size Price Availability Quantity
1g USD 55 In stock
2g USD 85 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 149.21
Formula C5H11NO2S
CAS Number 348-67-4
Purity >98%
Solubility Water ≥ 20 mg/mL
Storage 4°C, protect from light, dry, sealed

D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat.
Hinduja S, et al. Neurotox Res. 2015 Apr;27(3):199-204. PMID: 25488710.

Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitro studies using human plasma.
Sooriyaarachchi M, et al. Metallomics. 2014 Mar;6(3):532-41. PMID: 24337005.

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Keywords: Methionine, D-Methionine; MRX-1024 supplier, GABA Receptor, inhibitors

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