The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water ≥ 20 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat.
Hinduja S, et al. Neurotox Res. 2015 Apr;27(3):199-204. PMID: 25488710.
Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitro studies using human plasma.
Sooriyaarachchi M, et al. Metallomics. 2014 Mar;6(3):532-41. PMID: 24337005.
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