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Metamizole sodium hydrate

Cat. No. M5773
Metamizole sodium hydrate Structure
Size Price Availability Quantity
500mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Metamizole (Dipyrone) sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 351.35
Formula C13H18N3NaO5S
CAS Number 5907-38-0
Purity >99%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

Metamizole-associated adverse events: a systematic review and meta-analysis.
Kötter T, et al. PLoS One. 2015 Apr 13;10(4):e0122918. PMID: 25875821.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Metamizole sodium hydrate supplier, COX, inhibitors

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