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Cat. No. M9268
Met-Enkephalin Structure


Size Price Availability Quantity
10mg USD 60 In stock
25mg USD 110 In stock
50mg USD 180 In stock
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Quality Control
Biological Activity

Met-Enkephalin is an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. Met-Enkephalin (H-Tyr-Gly-Gly-Phe-Met-OH) changes the tumor microenvironment by binding to opioid receptor on or in cancer cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 573.66
Formula C27H35N5O7S
CAS Number 58569-55-4
Purity 99.78%
Solubility DMSO: ≥ 23 mg/mL
Storage at -20°C

Methionine enkephalin, its role in immunoregulation and cancer therapy.
Zhao D, et al. Int Immunopharmacol. 2016 Aug;37:59-64. PMID: 26927200.

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Keywords: Met-Enkephalin, H-Tyr-Gly-Gly-Phe-Met-OH supplier, Opioid Receptor, inhibitors

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