Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine is described to demonstrate inhibition for D2DR and D4DR. High affinity for the cloned rat dopamine D4 receptor (Ki20 nM). Antipsychotic agent.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel.
Su Z, et al. J Mol Cell Cardiol. 2004 Jan;36(1):151-60. PMID: 14734057.
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|Prochlorperazine dimaleate salt
Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.
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