Free shipping on all orders over $ 500

Mesoridazine besylate

Cat. No. M3177
Mesoridazine besylate Structure
Size Price Availability
50mg USD 85 1-2 Weeks
100mg USD 150 1-2 Weeks
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine is described to demonstrate inhibition for D2DR and D4DR. High affinity for the cloned rat dopamine D4 receptor (Ki20 nM). Antipsychotic agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 544.75
Formula C21H26N2OS2.C6H6O3S
CAS Number 32672-69-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel.
Su Z, et al. J Mol Cell Cardiol. 2004 Jan;36(1):151-60. PMID: 14734057.

Related Dopamine Receptor Products
Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

rac-Rotigotine (Hydrochloride)

rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.

Promazine HCl

Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

Pramipexole dihydrochloride

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mesoridazine besylate supplier, Dopamine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.