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Mertansine

Cat. No. M5222
Mertansine Structure
Synonym:

DM1, Maytansinoid

Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 150 In stock
25mg USD 300 In stock
50mg USD 520 In stock
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Quality Control
Biological Activity

Mertansine is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at sub-nanomolar concentrations. Mertansine at a concentration of 100 nmol/L suppressed the growth and shortening rates by 35%, quantitatively similarly to the same concentration of vinblastine. Mertansine inhibits the formation of a cross-link between Cys 12 and Cys 201

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 738.29
Formula C35H48ClN3O10S
CAS Number 139504-50-0
Purity 98.77%
Solubility 10 mM in DMSO
Storage at -20°C
References

Phase 1/2 Study of the CD56-Targeting Antibody-Drug Conjugate Lorvotuzumab Mertansine (IMGN901) in Combination With Carboplatin/Etoposide in Small-Cell Lung Cancer Patients With Extensive-Stage Disease.
Socinski MA, et al. Clin Lung Cancer. 2017 Jan;18(1):68-76. PMID: 28341109.

Harnessing the Immune System Against Leukemia: Monoclonal Antibodies and Checkpoint Strategies for AML.
Masarova L, et al. Adv Exp Med Biol. 2017;995:73-95. PMID: 28321813.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mertansine, DM1, Maytansinoid supplier, Microtubule, inhibitors

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