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Mercaptopurine (6-MP)

Cat. No. M5771

Mercaptopurine (6-MP) Structure
Size Price Availability Quantity
100mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 152.18
Formula C5H4N4S
CAS Number 50-44-2
Purity >99%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes.
LaDuke KE, et al. Am J Vet Res. 2015 Jul;76(7):649-55. PMID: 26111096.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mercaptopurine (6-MP) supplier, DNA/RNA Synthesis, inhibitors

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