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Menadione

Cat. No. M5767

Menadione Structure

Synonym: Vitamin K3

Size Price Availability Quantity
500mg USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 172.18
Formula C11H8O2
CAS Number 58-27-5
Purity >99%
Solubility 34 mg/mL in DMSO
Storage at -20°C
References

Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion.
Kim YJ, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Sep;387(9):799-809. PMID: 24879465.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Menadione, Vitamin K3 supplier, DNA/RNA Synthesis, inhibitors

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