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MEGX

Cat. No. M8226
MEGX Structure
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Biological Activity

Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

Chemical Information
Molecular Weight 206.28
Formula C12H18N2O
CAS Number 7728-40-7
Solubility (25°C) Water: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Oellerich, et al. The MEGX test: a tool for the real-time assessment of hepatic function

[2] V Kupcov. Importance of determination of monoethylglycinexylidide (MEGX)--as a liver function test in hepatology and liver transplantation

[3] R Orlando, et al. The effect of age on plasma MEGX concentrations

[4] C Reichel, et al. Monoethylglycinexylidide (MEGX)-test. A test for the assessment of prognosis before and after liver transplantation

[5] A H Thomson, et al. The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects

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Keywords: MEGX supplier, inhibitors, activators


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