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Mefenamic Acid

Cat. No. M2835
Mefenamic Acid Structure
Size Price Availability Quantity
500mg USD 60  USD60 In stock
5g USD 100  USD100 In stock
10g USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.

Chemical Information
Molecular Weight 241.29
Formula C15H15NO2
CAS Number 61-68-7
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nurul Iftida Basri, et al. Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea

[2] Nevio Cimolai. The potential and promise of mefenamic acid

[3] Rachel Moll, et al. Single dose oral mefenamic acid for acute postoperative pain in adults

[4] No authors listed. Br Med J. Mefenamic acid

[5] G R Singh, et al. Mefenamic acid

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Keywords: Mefenamic Acid supplier, COX, inhibitors, activators


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