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ME0328

Cat. No. M2831
ME0328 Structure
Size Price Availability Quantity
10mg USD 90 In stock
25mg USD 180 In stock
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Quality Control
Biological Activity

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 321.37
Formula C19H19N3O2
CAS Number 1445251-22-8
Purity 99.46%
Solubility DMSO 54 mg/mL
Storage at -20°C
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Niraparib (MK-4827) tosylate

Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.

Daidzein

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NMS-P118

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ME0328 supplier, PARP, inhibitors

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