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Maytansinol

Cat. No. M8967
Maytansinol Structure
Synonym:

Ansamitocin P-0

Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 170 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 565.06
Formula C28H37ClN2O8
CAS Number 57103-68-1
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells.
Edwards A, et al. Dis Model Mech. 2011 Jul;4(4):496-503. PMID: 21504911.

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Keywords: Maytansinol, Ansamitocin P-0 supplier, Microtubule, inhibitors

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