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Mannide monooleate

Cat. No. M9915
Mannide monooleate Structure
Size Price Availability Quantity
10mL USD 50  USD50 In stock
25mL USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Mannide monooleate is an emulsifying agent utilized in Freund′s incomplete adjuvant. Mannide monooleate is a lipohilic surfactant. It is also a non-ionic surface active emulsifier.

Chemical Information
Molecular Weight 428.6
Formula C24H44O6
CAS Number 9049-98-3
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elisabeth J M Huijbers, et al. Vaccine. The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B--a prerequisite for clinical development

[2] R O Williams 3rd, et al. Drυg Dev Ind Pharm. Preformulation studies on Freund's incomplete adjuvant emulsion

[3] Jerome Aucouturier, et al. Expert Rev Vaccines. Montanide ISA 720 and 51: a new generation of water in oil emulsions as adjuvants for human vaccines

[4] J N Bollinger. J Pharm Sci. Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. II. Mannide monooleate

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