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Malathion

Cat. No. M14549
Malathion Structure
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Biological Activity

Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase, is an insecticide of relatively low human toxicity.

Chemical Information
Molecular Weight 330.36
CAS Number 121-75-5
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yoshikazu Yamagishi, et al. Effects of human serum albumin on post-mortem changes of malathion

[2] Smita S Kumar, et al. A comprehensive review on enzymatic degradation of the organophosphate pesticide malathion in the environment

[3] Tatenda Madzorera, et al. Malathion-filled trilayer polyolefin film for malaria vector control

[4] Baljinder Singh, et al. Microbial degradation of an organophosphate pesticide, malathion

[5] Shereene Idriss, et al. Malathion for head lice and scabies: treatment and safety considerations

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