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Lusutrombopag

Cat. No. M9458
Lusutrombopag Structure
Synonym:

S-888711

Size Price Availability Quantity
2mg USD 110  USD110 In stock
5mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist. Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes.

Chemical Information
Molecular Weight 591.55
Formula C29H32Cl2N2O5S
CAS Number 1110766-97-6
Solubility (25°C) DMSO ≥ 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Lusutrombopag

[2] Naim Alkhouri, et al. Lusutrombopag Is Safe and Efficacious for Treatment of Thrombocytopenia in Patients With and Without Hepatocellular Carcinoma

[3] Yuki Tsuji, et al. Effectiveness of Lusutrombopag in Patients with Mild to Moderate Thrombocytopenia

[4] Matt Shirley, et al. Lusutrombopag: A Review in Thrombocytopenia in Patients with Chronic Liver Disease Prior to a Scheduled Procedure

[5] Markus Peck-Radosavljevic, et al. Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L-PLUS 2)

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Keywords: Lusutrombopag, S-888711 supplier, Thrombopoietin/Thrombin, inhibitors, activators


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