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LT-628

Cat. No. M1857
LT-628 Structure
Size Price Availability
10mg USD 280  USD280 Out of stock
25mg USD 480  USD480 Out of stock
50mg USD 720  USD720 Out of stock
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Quality Control & Documentation
Biological Activity

LT-628 is the racemate of BMN 673 and LT-674. Poly ADP-ribose polymerase, or PARP, plays a key role in DNA repair by detecting and initiating repair if a DNA strand breaks.

Chemical Information
Molecular Weight 380.35
Formula C19H14F2N6O
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related PARP Products
DSB-1522

DSB-1522 is a PARP1 inhibitor that can be used in tumor-related studies.

DM-5167

DM-5167 is a PARP1 inhibitor that can be used in studies related to triple negative breast cancer.

NMS-03305293

NMS-03305293 is a PARP inhibitor with high selectivity for PARP1 isoforms and low DNA capture effect, which specifically kills BRCA mutated tumor cells. In addition, NMS-03305293 can penetrate the blood-brain barrier and can be used in studies related to CNS tumors and brain metastatic tumors.

SNV1521

SNV1521 is a potential best-in-class (BIC), highly selective and CNS-permeable PARP1 inhibitor.

Basroparib

Basroparib is an orally active selective inhibitor of end-anchor polymerase (TNKS) and an inhibitor of ribose polymerase (PARP) with antitumor activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: LT-628 supplier, PARP, inhibitors, activators


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