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LT-626

Cat. No. M3703

LT-626 Structure
Size Price Availability Quantity
5mg USD 380 In stock
10mg USD 580 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LT-626 inhibits PARP-1 activity.LT-626 is a PARP inhibitor that is able to inhibit PARP enzymatic activity and cellular PAR synthesis in the same nanomolar range as the previously characterized PARP inhibitors veliparib and olaparib while demonstrating greater potency than both of them in a cellular cytotoxicity assay.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >99%
Solubility
Storage at -20°C
Product Citations
References

Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
McPherson LA, et al. Cancer Lett. 2014 Feb 28;343(2):217-23. PMID: 24215868.

Abstract 5490: Poly (ADP-ribose) polymerase inhibitor LT-626 sensitizes lung and pancreatic cancers to fractionated radiation therapy
Kedar Hastak, et al. Cancer Research. 2014 Oct 1.

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BMN673 isomer

BMN-673 8R,9S

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LT-626 supplier, PARP, inhibitors

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