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LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)

Cat. No. M14946
LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) Structure
Synonym:

(TSP-1)

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 145  USD145 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 572.62
Formula
CAS Number 283609-79-0(free base)
Purity >99%
Solubility DMSO 150 mg/mL
Water 90 mg/mL
Storage -20°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog




Keywords: LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA), (TSP-1) supplier, TGF-beta/Smad, inhibitors

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