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Loxapine

Cat. No. M5754
Loxapine Structure
Size Price Availability Quantity
100mg USD 80 In stock
500mg USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 327.81
Formula C18H18ClN3O
CAS Number 1977-10-2
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Loxapine add-on for adolescents and adults with autism spectrum disorders and irritability.
Hellings JA, et al, J Child Adolesc Psychopharmacol. 2015 Mar;25(2):150-9. PMID: 25782098.

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  Catalog
Abmole Inhibitor Catalog 2017




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