Free shipping on all orders over $ 500

Losartan

Cat. No. M9056
Losartan Structure
Synonym:

DUP-89

Size Price Availability Quantity
1g USD 70 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Losartan is an antagonist of angiotensin II receptor with antihypertensive activity due to the reduced pressor effect of angiotensin II. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 422.91
Formula C22H23ClN6O
CAS Number 114798-26-4
Purity 100.00%
Solubility DMSO: ≥ 90 mg/mL
Storage at -20°C
References

Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells.
Ashry O, et al. Respir Physiol Neurobiol. 2014 May 1;195:37-40. PMID: 24530803.

Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells.
Choi CH, et al. Gynecol Oncol. 2012 Jul;126(1):124-31. PMID: 22525818.

Related Angiotensin Receptor Products
A-779

A-779 is a specific antagonist of G-protein coupled receptor (Mas receptor).

Angiotensin-(1-7)

Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM.

EMA401

EMA401 (also known as Olodanrigan and PD-126055) is a highly selective angiotensin AT2 antagonist.

Angiotensin II human

Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.

Tranilast

Tranilast is an antiallergic agent.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Losartan, DUP-89 supplier, Angiotensin Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.