Losartan is an antagonist of angiotensin II receptor with antihypertensive activity due to the reduced pressor effect of angiotensin II. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO: ≥ 80 mg/mL|
|Related Angiotensin Receptor Products|
|C-Type Natriuretic Peptide (CNP) (1-22), human
C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.
AVE 0991 is an orally active agonist of angiotensin-(1-7) receptor with IC50 of 21 nM.
TRV-120027 (also known as TRV027) is an angiotensin II receptor type 1 (AT1R) antagonist and engages ß-arrestins while blocking G-protein signaling.
BIBS39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
A-779 is a specific antagonist of G-protein coupled receptor (Mas receptor).
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