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Loratadine

Cat. No. M5752
Loratadine Structure
Synonym:

SCH29851

Size Price Availability Quantity
10mg USD 55 In stock
50mg USD 120 In stock
100mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 382.88
Formula C22H23ClN2O2
CAS Number 79794-75-5
Purity >99%
Solubility 76 mg/mL in Ethanol
Storage at -20°C
References

Loratadine analogues as MAGL inhibitors.
Patel JZ, et al. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42. PMID: 25752982.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Loratadine, SCH29851 supplier, Histamine Receptor, inhibitors

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